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Article

PED/PEA‐15 controls fibroblast motility and wound closure by ERK1/2‐dependent mechanisms

21 Jul 2011

Abstract excerpt

Cell migration is dependent on the control of signaling events that play significant roles in creating contractile force and in contributing to wound closure. We evaluated wound closure in fibroblasts from mice overexpressing (TgPED) or lacking ped/pea-15 (KO), a gene overexpressed in patients with type 2 diabetes. Cultured skin fibroblasts isolated from TgPED mice showed a significant reduction in the ability to...

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PMID: 21780113
DOI: 10.1002/jcp.22944

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