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Article

Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability.

Journal of biomedical science - 3 Feb 2010

Jiang Qifeng, Huang Renjian, Cai Shaoxi, Wang Chih-Lueh A

Abstract excerpt

BACKGROUND: Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC motility, the roles of caldesmon (CaD) and its phosphorylation were investigated. METHODS: We have performed Transwell migration assays, immunofluorescence microscopy, traction microscopy and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 20128924
DOI: 10.1186/1423-0127-17-6
PMCID: PMC2846900

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