Article
Phosphorylated l-caldesmon is involved in disassembly of actin stress fibers and postmitotic spreading.
Experimental cell research - 15 Jan 2006
Kordowska Jolanta, Hetrick Tracy, Adam Leonard P, Wang C-L Albert
Abstract excerpt
The function of the ubiquitous actin-binding protein, caldesmon (l-CaD) in mammalian non-muscle cells remains elusive. During mitosis, l-CaD becomes markedly phosphorylated at Ser497 and Ser527 (in the rat sequence), therefore, it has been suggested that l-CaD is involved in cytokinesis by inhibiting the actomyosin interaction until it is phosphorylated, although direct in vivo evidence is still missing. In the...
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