Article
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
Molecular and cellular biology - 1 Mar 1997
Manser E, Huang H Y, Loo T H, Chen X Q, Dong J M, Leung T, Lim L
Abstract excerpt
The family of p21-activated protein kinases (PAKs) appear to be present in all organisms that have Cdc42-like GTPases. In mammalian cells, PAKs have been implicated in the activation of mitogen-activated protein kinase cascades, but there are no reported effects of these kinases on the cytoskelet...
Topics
- Actins
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Adhesion
- Cell Cycle Proteins
- Cytoskeleton
- Enzyme Activation
- GTP-Binding Proteins
- Gene Expression
- Guanosine 5'-O-(3-Thiotriphosphate)
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinases
- Recombinant Fusion Proteins