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Article

Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.

Molecular biology of the cell - 1 Oct 1999

Helfman D M, Levy E T, Berthier C, Shtutman M, Riveline D, Grosheva I, Lachish-Zalait A, Elbaum M, Bershadsky A D

Abstract excerpt

Caldesmon is known to inhibit the ATPase activity of actomyosin in a Ca(2+)-calmodulin-regulated manner. Although a nonmuscle isoform of caldesmon is widely expressed, its functional role has not yet been elucidated. We studied the effects of nonmuscle caldesmon on cellular contractility, actin cytoskeletal organization, and the formation of focal adhesions in fibroblasts. Transient transfection of nonmuscle...

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Identifiers

PMID: 10512853
DOI: 10.1091/mbc.10.10.3097
PMCID: PMC25564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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