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Article

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.

The Journal of cell biology - 27 Jun 2011

Delorme-Walker Violaine D, Peterson Jeffrey R, Chernoff Jonathan, Waterman Clare M, Danuser Gaudenz, DerMardirossian Céline, Bokoch Gary M

Abstract excerpt

Cell motility requires the spatial and temporal coordination of forces in the actomyosin cytoskeleton with extracellular adhesion. The biochemical mechanism that coordinates filamentous actin (F-actin) assembly, myosin contractility, adhesion dynamics, and motility to maintain the balance between adhesion and contraction remains unknown. In this paper, we show that p21-activated kinases (Paks), downstream...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21708980
DOI: 10.1083/jcb.201010059
PMCID: PMC3216326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.PMID 21708980Read ↗

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