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Article

Phosphorylation of actopaxin regulates cell spreading and migration.

The Journal of cell biology - 13 Sept 2004

Clarke Dominic M, Brown Michael C, LaLonde David P, Turner Christopher E

Abstract excerpt

Actopaxin is an actin and paxillin binding protein that localizes to focal adhesions. It regulates cell spreading and is phosphorylated during mitosis. Herein, we identify a role for actopaxin phosphorylation in cell spreading and migration. Stable clones of U2OS cells expressing actopaxin wild-type (WT), nonphosphorylatable, and phosphomimetic mutants were developed to evaluate actopaxin function. All proteins...

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Identifiers

PMID: 15353548
DOI: 10.1083/jcb.200404024
PMCID: PMC2172128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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