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Article

Identification of a constitutively active mutant of JAK3 by retroviral expression screening.

Leukemia research - 1 Feb 2007

Choi Young Lim, Kaneda Ruri, Wada Tomoaki, Fujiwara Shin-Ichiro, Soda Manabu, Watanabe Hideki, Kurashina Kentaro, Hatanaka Hisashi, Enomoto Munehiro, Takada Shuji, Yamashita Yoshihiro, Mano Hiroyuki

Abstract excerpt

To identify transforming genes in acute myeloid leukemia (AML) we here constructed a retroviral cDNA expression library from an AML patient, and then used this library to infect a mouse cell line 32Dcl3-mCAT. cDNA inserts of the cell clones which proliferated in the presence of granulocyte colony-stimulating factor were derived from JAK3 encoding a JAK3 mutant with a valine-to-alanine substitution at codon 674...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cloning, Molecular

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Source

Identifiers

PMID: 16790275
DOI: 10.1016/j.leukres.2006.05.006

Genes

JAK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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