Article
Activation of the gene for the PDGF receptor beta1 (PDGFRbeta) in interleukin-3-dependent myeloid cells by retroviral insertional mutagenesis: implications for the transforming potential of PDGFRbeta.
Growth factors (Chur, Switzerland) - 1 Sept 2002
Meyer Johann, Laker Christine, Janzir Nadia, Franz Marie-Joseé, Bergholz Ursula, Ostertag Wolfram, Stocking Carol
Abstract excerpt
Retroviral insertional mutagenesis has proven to be a powerful tool to identify genetic lesions disrupting normal hematopoiesis. The gene encoding the beta receptor for platelet-derived growth factor (PDGFRbeta) was identified as a target of retroviral mutagenesis in mutants selected for interleukin-3 (IL3)-independent growth. Expression of PDGFRbeta in the parental cells using a retroviral vector increased the...
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