Article
Hematopoietic transforming potential of activated ras in chimeric mice.
Oncogene - 21 Sept 1995
Hawley R G, Fong A Z, Ngan B Y, Hawley T S
Abstract excerpt
Although activating mutations in ras genes are the most common genetic abnormality in human hematologic malignancies, the role of ras mutations as an initiating event in leukemogenesis remains unclear. To assess the consequences of ectopic expression of an activated ras gene in normal hematopoiet...
Topics
- Animals
- Burkitt Lymphoma
- Cell Transformation, Neoplastic
- Chimera
- Female
- Gene Rearrangement
- Genes, ras
- Hematopoiesis
- Hematopoietic Stem Cells
- Lymphoma
- Mice
- Mice, Inbred BALB C
- Mutation
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Proviruses
- Retroviridae