Article
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.
Blood - 25 Jan 2018
Degryse Sandrine, Bornschein Simon, de Bock Charles E, Leroy Emilie, Vanden Bempt Marlies, Demeyer Sofie, Jacobs Kris, Geerdens Ellen, Gielen Olga, Soulier Jean, Harrison Christine J, Constantinescu Stefan N, Cools Jan
Abstract excerpt
The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitutive JAK/STAT signaling and cause leukemia when expressed in the bone marrow cells of mice. Surprisingly, we observed that one third of JAK3-mutant T-ALL cases harbor 2 JAK3 mutations, some of which are monoallelic and others that are biallelic. Our data suggest that...
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