Back to search

Article

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.

1991-04-01

Abstract excerpt

vav, a novel human oncogene, was originally generated in vitro by replacement of its normal 5' coding sequences with sequences from pSV2neo DNA, cotransfected as a selectable marker (S. Katzav, D. Martin-Zanca, and M. Barbacid, EMBO J. 8:2283-2290, 1989). The vav proto-oncogene is normally expressed in cells of hematopoietic origin. To determine whether the 5' rearrangement of vav or its ectopic expression in NIH...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5319b058-9b6b-5ed5-8fa8-5c23ac1b7ad6
DOI
10.1128/mcb.11.4.1912
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.DOI 10.1128/mcb.11.4.1912
Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.Semantic proximity
Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons from Mouse Models.Semantic proximity
Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Semantic proximity
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.Semantic proximity
The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomasSemantic proximity
Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Semantic proximity
Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.Semantic proximity
MYC Analysis in Cancer and Evolution.Semantic proximity
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.Semantic proximity
PU.1 regulates the expression of the vav proto-oncogene.Semantic proximity
Mutation of Vav1 adaptor region reveals a new oncogenic activation.Semantic proximity
Vav1 mutations: What makes them oncogenic?Semantic proximity
Select a neighboring publication to make it the new centre.