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Article

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia.

Oncogene - 4 Jun 2015

Agarwal A, MacKenzie R J, Eide C A, Davare M A, Watanabe-Smith K, Tognon C E, Mongoue-Tchokote S, Park B, Braziel R M, Tyner J W, Druker B J

Abstract excerpt

To understand the role of cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis, we designed a functional RNA interference (RNAi) screen targeting 188 cytokine and growth factor receptors that we found highly expressed in primary leukemia specimens. Using this screen, we identified interleukin-2 gamma receptor (IL2Rγ) as a critical growth determinant for a JAK3(A572V) mutation-positive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Interleukin Receptor Common gamma Subunit

Share to Janus Kinase 3

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Source

Open in PubMed Open full text

Identifiers

PMID: 25109334
DOI: 10.1038/onc.2014.243
PMCID: PMC4324389

Genes

JAK3
JAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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