Article
Retroviral expression screening of oncogenes in natural killer cell leukemia.
Leukemia research - 1 Aug 2005
Choi Young Lim, Moriuchi Ryozo, Osawa Mitsujiro, Iwama Atsushi, Makishima Hideki, Wada Tomoaki, Kisanuki Hiroyuki, Kaneda Ruri, Ota Jun, Koinuma Koji, Ishikawa Madoka, Takada Shuji, Yamashita Yoshihiro, Oshimi Kazuo, Mano Hiroyuki
Abstract excerpt
Aggressive natural killer cell leukemia (ANKL) is an intractable malignancy that is characterized by the outgrowth of NK cells. To identify transforming genes in ANKL, we constructed a retroviral cDNA expression library from an ANKL cell line KHYG-1. Infection of 3T3 cells with recombinant retroviruses yielded 33 transformed foci. Nucleotide sequencing of the DNA inserts recovered from these foci revealed that 31...
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