Article
Activating alleles of JAK3 in acute megakaryoblastic leukemia.
Cancer cell - 1 Jul 2006
Walters Denise K, Mercher Thomas, Gu Ting-Lei, O'Hare Thomas, Tyner Jeffrey W, Loriaux Marc, Goss Valerie L, Lee Kimberly A, Eide Christopher A, Wong Matthew J, Stoffregen Eric P, McGreevey Laura, Nardone Julie, Moore Sandra A, Crispino John, Boggon Titus J, Heinrich Michael C, Deininger Michael W, Polakiewicz Roberto D, Gilliland D Gary, Druker Brian J
Abstract excerpt
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we developed a screening strategy that rapidly identifies tyrosine-phosphorylated proteins using mass spectrometry. This allowed the identification of an activating mutation (A572V) in the JAK3 pseudokinase domain in the acute megakaryoblastic leukemia (AMKL)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.