Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: findings and recommendations.

doi:10.18632/oncotarget.15392

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Article

Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: findings and recommendations.

Oncotarget - 21 Feb 2017

Watanabe-Smith Kevin, Godil Jamila, Agarwal Anupriya, Tognon Cristina, Druker Brian

Abstract excerpt

The identification and functional validation of potentially oncogenic mutations in leukemia is an essential step toward a future of personalized targeted therapy. To assess the oncogenic capacity of individual mutations, reliable and scalable in vitro experimental approaches are required. Since 1988, researchers have used the IL-3 dependent Ba/F3 transformation assay to validate the oncogenic potential of...

Topics

Animals
Cell Line, Tumor
Cell Transformation, Neoplastic
Genetic Techniques
Leukemia
Mice
Mutation
Transgenes

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Identifiers

PMID: 28208123
DOI: 10.18632/oncotarget.15392
PMCID: PMC5355038

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