COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.

doi:10.1002/ajmg.b.32440

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Article

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2016

Dean Brian, Scarr Elizabeth

Abstract excerpt

Catechol-O-methyltransferase (COMT) genotype has been associated with varying levels of cognitive functioning and an altered risk of schizophrenia. COMT regulates the breakdown of catecholamines, particularly dopamine, which is thought critical in maintaining cognitive function and the aetiology of schizophrenia. This hypothesis gained support from reports that the VAL allele at rs4680 was associated with poorer...

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Identifiers

PMID: 26954460
DOI: 10.1002/ajmg.b.32440

Genes

COMT
CHRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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