Article
Heritability of baseline and induced micronucleus frequencies.
Mutagenesis - 1 Jan 2011
Surowy Harald, Rinckleb Antje, Luedeke Manuel, Stuber Madeleine, Wecker Anna, Varga Dominic, Maier Christiane, Hoegel Josef, Vogel Walther
Abstract excerpt
The scoring of micronuclei (MN) is widely used in biomonitoring and mutagenicity testing as a surrogate marker of chromosomal damage inflicted by clastogenic agents or by aneugens. Individual differences in the response to a mutagenic challenge are known from studies on cancer patients and carriers of mutations in DNA repair genes. However, it has not been studied to which extent genetic factors contribute to the...
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