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Article

New approaches to assessing the effects of mutagenic agents on the integrity of the human genome.

Mutation research - 1 Mar 2007

Elespuru R K, Sankaranarayanan K

Abstract excerpt

Heritable genetic alterations, although individually rare, have a substantial collective health impact. Approximately 20% of these are new mutations of unknown cause. Assessment of the effect of exposures to DNA damaging agents, i.e. mutagenic chemicals and radiations, on the integrity of the human genome and on the occurrence of genetic disease remains a daunting challenge. Recent insights may explain why...

Topics

Congenital Abnormalities
Environmental Pollutants
Forecasting
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Genome, Human
Genomic Instability
Germ Cells
Germ-Line Mutation
Humans
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Risk Assessment

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Identifiers

PMID: 17174354
DOI: 10.1016/j.mrfmmm.2006.11.015

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