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Article

Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.

Circulation research - 7 Jul 2006

Blankenberg Stefan, Godefroy Tiphaine, Poirier Odette, Rupprecht Hans J, Barbaux Sandrine, Bickel Christoph, Nicaud Viviane, Schnabel Renate, Kee Frank, Morrison Caroline, Evans Alun, Lackner Karl J, Cambien François, Münzel Thomas, Tiret Laurence

Abstract excerpt

Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag SNPs captured 4 common haplotypes of the CASP1 gene. Among these, the A(in6) allele of the...

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Identifiers

PMID: 16778130
DOI: 10.1161/01.RES.0000232324.87983.4b

Genes

CASP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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