Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease.

PloS one - 1 Jan 2015

Gigante Bruna, Strawbridge Rona J, Velasquez Ilais Moreno, Golabkesh Zahra, Silveira Angela, Goel Anuj, Baldassarre Damiano, Veglia Fabrizio, Tremoli Elena, Clarke Robert, Watkins Hugh, Hamsten Anders, Humphries Steve E, de Faire Ulf

Abstract excerpt

Variants at the interleukin 6 receptor (IL6R) gene regulate inflammation and are associated with risk of coronary heart disease (CHD). The aim of the present study was to investigate the effects of IL6R haplotypes on circulating levels of inflammatory biomarkers and risk of CHD. We performed a discovery analysis in SHEEP, a myocardial infarction (MI) case control study (n = 2,774) and replicated our results in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to C-Reactive Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Fibrinogen

Share to Haplotypes

Share to Interleukin-8

Share to Receptors, Interleukin-6

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 25781951
DOI: 10.1371/journal.pone.0119980
PMCID: PMC4364007

Genes

CRP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease.PMID 25781951Read ↗

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.Semantic proximity Read ↗

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.Semantic proximity Read ↗

Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis.Semantic proximity Read ↗

Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels.Semantic proximity Read ↗

Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction.Semantic proximity Read ↗

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.Semantic proximity Read ↗

The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.Semantic proximity Read ↗

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Semantic proximity Read ↗

Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction.Semantic proximity Read ↗

Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.Semantic proximity Read ↗

Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women's health initiative.Semantic proximity Read ↗

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.