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Article

Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction.

Atherosclerosis - 1 Mar 2009

van Minkelen Rick, Wettinger Stephanie Bezzina, de Visser Marieke C H, Vos Hans L, Reitsma Pieter H, Rosendaal Frits R, Bertina Rogier M, Doggen Carine J M

Abstract excerpt

BACKGROUND: The overall effect of the major pro-inflammatory cytokine interleukin-1 (IL-1) on coagulation and fibrinolysis is prothrombotic. We recently found that haplotype 5 (H5) of the gene (IL1RN) coding for the interleukin-1 receptor antagonist (IL-1Ra), the natural inhibitor of IL-1, is associated with an increased risk of venous thrombosis. It is unclear whether variations in IL1RN affect the risk of...

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Identifiers

PMID: 18703194
DOI: 10.1016/j.atherosclerosis.2008.06.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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