Article
The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study.
Mechanisms of ageing and development - 1 Aug 2004
Licastro Federico, Chiappelli Martina, Caldarera Claudio Marcello, Tampieri Cecilia, Nanni Samuele, Gallina Margherita, Branzi Angelo
Abstract excerpt
Genetic background of inflammatory or anti-inflammatory molecules may be helpful in identifying subjects with increased or decrease risk of developing cardiovascular disease. Bi-allele polymorphism (C > T) in the promoter region (-511) of the interleukin-1beta (IL-1beta) gene and the bi-allele polymorphism (G > C) in the promoter region (-174) of interleukin-6 (IL-6) gene were determined in elderly men patients...
Topics
- Aged
- Alleles
- Apolipoproteins E
- Humans
- Inflammation
- Interleukin-1
- Interleukin-6
- Male
- Middle Aged
- Myocardial Infarction