Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.

Circulation - 2 Aug 2005

Tiret Laurence, Godefroy Tiphaine, Lubos Edith, Nicaud Viviane, Tregouet David-Alexandre, Barbaux Sandrine, Schnabel Renate, Bickel Christoph, Espinola-Klein Christine, Poirier Odette, Perret Claire, Münzel Thomas, Rupprecht Hans-Jurgen, Lackner Karl, Cambien François, Blankenberg Stefan

Abstract excerpt

BACKGROUND: Interleukin (IL)-18 plays a key role in atherosclerosis and its complications. The present study investigated the genetic variability of 4 genes of the IL-18 system-IL18, IL18R1, IL18RAP, and IL18BP-in relation to circulating IL-18 levels and cardiovascular mortality. METHODS AND RESULTS: Twenty-two polymorphisms were genotyped in 1288 patients with coronary artery disease prospectively followed up...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-18

Share to Patient Selection

Share to Polymorphism, Genetic

Share to Risk Factors

Share to RNA, Messenger

Share to Treatment Outcome

Source

Identifiers

PMID: 16043644
DOI: 10.1161/CIRCULATIONAHA.104.519702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.PMID 16043644Read ↗

IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease.Semantic proximity Read ↗

Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project.Semantic proximity Read ↗

IL-18 gene polymorphism, cardiovascular mortality and coronary artery disease.Semantic proximity Read ↗

Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study.Semantic proximity Read ↗

Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project.Semantic proximity Read ↗

IL18-family Genes Polymorphism Is Associated with the Risk of Myocardial Infarction and IL18 Concentration in Patients with Coronary Artery Disease.Semantic proximity Read ↗

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization StudySemantic proximity Read ↗

Interleukin 18 gene variation and risk of acute myocardial infarction.Semantic proximity Read ↗

Interleukin 18 and coronary heart disease: prospective study and systematic review.Semantic proximity Read ↗

Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men.Semantic proximity Read ↗

Genotyping of interleukins-18 promoters and their correlation with coronary artery stenosis in Saudi population.Semantic proximity Read ↗

Major Adverse Cardiovascular Events: The Importance of Serum Levels and Haplotypes of the Anti-Inflammatory Cytokine Interleukin 10.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.