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Article

Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction.

Circulation research - 11 Nov 2005

Pearce Eve, Tregouet David-Alexandre, Samnegård Ann, Morgan Angharad R, Cox Charles, Hamsten Anders, Eriksson Per, Ye Shu

Abstract excerpt

Myocardial infarction (MI) is commonly caused by atherosclerotic plaque rupture following excessive degradation of collagen fibers in the atherosclerotic lesion. We investigated whether interindividual variability in risk of MI was related to polymorphisms in the gene encoding matrix metalloproteinase (MMP)-1, a key fibrillar collagen-degrading enzyme. Several single nucleotide polymorphisms in the MMP1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16210545
DOI: 10.1161/01.RES.0000189302.03303.11

Genes

MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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