The -589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals.

doi:10.1111/j.1538-7836.2008.03096.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The -589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2008

Paffen E, Medina P, de Visser M C H, van Wijngaarden A, Zorio E, Estellés A, Rosendaal F R, España F, Bertina R M, Doggen C J M

Abstract excerpt

BACKGROUND: Inflammatory reactions contribute to the development of arterial disease. We investigated the role of interleukin-4 (IL-4) in the development of myocardial infarction (MI) by genotyping patients with MI and control subjects for the -589C>T (rs2243250) single nucleotide polymorphism (SNP), which tags a functional haplotype of IL-4. METHODS AND RESULTS: Study of Myocardial Infarctions Leiden (SMILE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Case-Control Studies

Share to Genotype

Share to Interleukin-4

Share to Myocardial Infarction

Share to Polymorphism, Single Nucleotide

Share to Risk

Source

Open in PubMed

Identifiers

PMID: 18662263
DOI: 10.1111/j.1538-7836.2008.03096.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The -589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals.PMID 18662263Read ↗

Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Témoin de l'Infarctus du Myocarde.Semantic proximity Read ↗

Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program.Semantic proximity Read ↗

Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics.Semantic proximity Read ↗

Common polymorphisms in the interleukin-6 gene and myocardial infarction risk: a meta-analysis.Semantic proximity Read ↗

Cytokine Gene Variants as Predisposing Factors for the Development and Progression of Coronary Artery Disease: A Systematic Review.Semantic proximity Read ↗

Association of interleukin-4 gene polymorphisms with ischemic heart failure.Semantic proximity Read ↗

Inflammatory cytokine gene variants in coronary artery disease patients in Greece.Semantic proximity Read ↗

Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells.Semantic proximity Read ↗

Functional polymorphisms of interleukin 4 and interleukin 10 may predict evolution and functional outcome of an ischaemic stroke.Semantic proximity Read ↗

The interleukin-1 cluster, dyslipidaemia and risk of myocardial infarction.Semantic proximity Read ↗

Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro.Semantic proximity Read ↗

Pharmacogenomics: a tool to prevent and cure coronary heart disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.