Article
Acceleration of alpha-synuclein aggregation by homologous peptides.
FEBS letters - 26 Jun 2006
Du Hai-Ning, Li Hong-Tao, Zhang Feng, Lin Xiao-Jing, Shi Jia-Hao, Shi Yan-Hong, Ji Li-Na, Hu Jun, Lin Dong-Hai, Hu Hong-Yu
Abstract excerpt
alpha-Synuclein (alpha-Syn), amyloid beta-protein and prion protein are among the amyloidogenic proteins that are associated with the neurodegenerative diseases. These three proteins share a homologous region with a consensus sequence mainly consisting of glycine, alanine and valine residues (accordingly named as the GAV motif), which was proposed to be the critical core for the fibrillization and cytotoxicity....
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