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Article

Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions.

Biochimica et biophysica acta - 1 Mar 2010

Zhou Wenbo, Long Chunmei, Reaney Stephen H, Di Monte Donato A, Fink Anthony L, Uversky Vladimir N

Abstract excerpt

Oxidative stress and aggregation of the presynaptic protein alpha-synuclein (alpha-Syn) are implied in the pathogenesis of Parkinson's disease and several other neurodegenerative diseases. Various posttranslational modifications, such as oxidation, nitration and truncation, have significant effects on the kinetics of alpha-Syn fibrillation in vitro. alpha-Syn is a typical natively unfolded protein, which...

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Identifiers

PMID: 20026206
DOI: 10.1016/j.bbadis.2009.12.004
PMCID: PMC2814895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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