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Article

Analysis of second-step mutations of class II and class III CHO aprt heterozygotes: chromosomal differences in deletion frequencies.

Somatic cell and molecular genetics - 1 May 1991

Belouchi A, Bradley W E

Abstract excerpt

We have determined the nucleotide sequence surrounding a BclI restriction fragment length variation near the aprt gene of CHO cells. By BclI digestion of the PCR-amplified DNA from a variety of APRT-deficient mutants derived from CHO cells, we were able to infer the following. First, all three heterozygotes of class II, which are known to undergo the second mutational step via a large deletion event occurring at...

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Source

Identifiers

PMID: 1675490
DOI: 10.1007/BF01232822

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of second-step mutations of class II and class III CHO aprt heterozygotes: chromosomal differences in deletion frequencies.PMID 1675490Read ↗

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