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Article

Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms.

Cancer research - 15 Mar 1990

Hakoda M, Nishioka K, Kamatani N

Abstract excerpt

Associations between germinal and somatic mutations at autosomal loci play an important role in the development of some tumors, including retinoblastoma. In an attempt to determine whether equivalent events occur in vivo at other loci, we cloned and enumerated somatic T-cells with mutations at the aprt locus, by taking advantage of both the presence of a human disease caused by genetic defects at this locus and...

Topics

2-Aminopurine
Adenine Phosphoribosyltransferase
Cells, Cultured
Clone Cells
Drug Resistance
Genetic Carrier Screening
Homozygote
Humans
Mutation
Pentosyltransferases
Reference Values

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T-Lymphocytes

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Identifiers

PMID: 2306728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2306728-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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