Article
Genetic instability on chromosome 16 in a human B lymphoblastoid cell line.
Somatic cell and molecular genetics - 1 Nov 1993
Smith L E, Grosovsky A J
Abstract excerpt
Mutagenesis at the aprt locus in TK6 human lymphoblasts has been found to occur at an unusually high rate (1.2 x 10(-9)) for a homozygous diploid locus. Evaluation of linked microsatellite polymorphisms demonstrated that loss of heterozygosity (LOH) accompanies conventional intragenic sequence al...
Topics
- Adenine Phosphoribosyltransferase
- Alleles
- B-Lymphocytes
- Cell Line
- Chromosomes, Human, Pair 16
- DNA Mutational Analysis
- DNA, Satellite
- Gene Amplification
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Heterozygote
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Mutagenesis, Site-Directed
- Mutation
- Polymorphism, Restriction Fragment Length
- Recombination, Genetic