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Article

Genetic instability on chromosome 16 in a human B lymphoblastoid cell line.

Somatic cell and molecular genetics - 1 Nov 1993

Smith L E, Grosovsky A J

Abstract excerpt

Mutagenesis at the aprt locus in TK6 human lymphoblasts has been found to occur at an unusually high rate (1.2 x 10(-9)) for a homozygous diploid locus. Evaluation of linked microsatellite polymorphisms demonstrated that loss of heterozygosity (LOH) accompanies conventional intragenic sequence alterations in each APRT- mutant. LOH occurred without allele preference. The extent of loss was highly uniform, ranging...

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Source

Identifiers

PMID: 7907433
DOI: 10.1007/BF01233379

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic instability on chromosome 16 in a human B lymphoblastoid cell line.PMID 7907433Read ↗

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