Article
Benzo[a]pyrenediol-epoxide induces loss of heterozygosity in Chinese hamster ovary cells heterozygous at the aprt locus.
Mutation research - 28 Oct 1996
Mazur-Melnyk M, Stuart G R, Glickman B W
Abstract excerpt
Benzo[a]pyrenediol-epoxide (BPDE), a metabolite of the ubiquitous environmental carcinogen benzo[a]pyrene (B[a]P), has been implicated as a point mutagen. However, as mutational events other than point mutations are also often associated with cancer, we have investigated whether BPDE can induce o...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adenine Phosphoribosyltransferase
- Animals
- Blotting, Southern
- CHO Cells
- Carcinogens, Environmental
- Cricetinae
- DNA Damage
- DNA Primers
- Heterozygote
- Mutagenesis
- Mutagens