Article
Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells.
Mutation research - 1 Jan 2000
Klinedinst D K, Drinkwater N R
Abstract excerpt
Expression of recessive mutant phenotypes can occur by a number of different mechanisms. Inactivation of the wild-type allele by base-substitution mutations, frameshift mutations or small deletions occurs at both hemizygous and heterozygous cellular loci, while other events, such as chromosome level rearrangements, may not be detected at hemizygous loci because of inviability of the resulting mutants. In order to...
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