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Article

Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism.

Journal of neuroimmunology - 1 Jun 1991

Charmley P, Beall S S, Concannon P, Hood L, Gatti R A

Abstract excerpt

Multiple sclerosis (MS) has been associated with particular HLA haplotypes and has recently been reported to also be associated with the T cell receptor (TCR) beta-chain complex. We have tried to determine the source of the TCR-beta/MS association by exploiting the pattern of linkage disequilibrium within the TCR-beta complex. We describe a new DNA polymorphism with the TCR variable region gene segment V beta 15...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 7
Gene Frequency
Genetic Linkage
Haplotypes
Humans
Multiple Sclerosis
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 1674514
DOI: 10.1016/0165-5728(91)90193-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1674514-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism.PMID 1674514Read ↗

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