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Article

Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes.

Journal of neuroimmunology - 1 Jun 1993

Beall S S, Biddison W E, McFarlin D E, McFarland H F, Hood L E

Abstract excerpt

Genetic makeup thought to affect susceptibility to multiple sclerosis (MS) and current evidence suggests that multiple genes may be involved. We have mapped a potential susceptibility gene or genes in the germ-line T cell receptor (TcR) V beta region of multiple sclerosis (MS) patients. Six restriction fragment length polymorphisms (RFLPs) spanning approximately 600 kb of the TcR V beta region were used to define...

Topics

Chromosome Mapping
Disease Susceptibility
Gene Frequency
Genes
Genotype
HLA-DR2 Antigen
Haplotypes
Histocompatibility Antigens Class II
Humans
Multiple Sclerosis
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 8101191
DOI: 10.1016/0165-5728(93)90163-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8101191-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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