Susceptibility to relapsing-progressive multiple sclerosis is associated with inheritance of genes linked to the variable region of the TcR beta locus: use of affected family-based controls.

doi:10.1086/301700

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Article

Susceptibility to relapsing-progressive multiple sclerosis is associated with inheritance of genes linked to the variable region of the TcR beta locus: use of affected family-based controls.

American journal of human genetics - 1 Feb 1998

Hockertz M K, Paty D W, Beall S S

Abstract excerpt

We tested the hypothesis that susceptibility to relapsing-progressive (RP) (but not to relapsing-remitting [RR]) multiple sclerosis (MS) is associated with a gene linked to the TcR beta-chain variable region delimited by the Vbeta8-BamHI and Vbeta11-BamHI RFLP alleles in DRw15+ MS patients, using...

Topics

Adult
Alleles
DNA
Deoxyribonuclease BamHI
Disease Susceptibility
Family
Female
Genetic Linkage
Genetic Variation
Humans
Lymphocytes
Male
Multiple Sclerosis
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Receptors, Antigen, T-Cell, alpha-beta
Recurrence

Source

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Identifiers

PMID: 9463308
DOI: 10.1086/301700
PMCID: PMC1376877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9463308-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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