Article
T cell receptor beta chain genotyping in Australian relapsing-remitting multiple sclerosis patients.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 2000
Buhler M M, Bennetts B H, Heard R N, Stewart G J
Abstract excerpt
This study focused on susceptibility to MS within the beta-chain of the T-cell antigen receptor (TCRB locus, 7q35) in a cohort of 122 RR-MS patients compared with 96 normal individuals using biallelic polymorphisms across the bv8s1(Vbeta8.1) to bv11s1 (Vbeta11) TCRB subregion. The markers bv6s5, bv8s1, bv10s1, bv15s1 and bv3s1 were studied for allele and genotype frequencies; haplotypes were assigned with...
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