IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination.

doi:10.1002/gcc.20345

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Article

IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination.

Genes, chromosomes & cancer - 1 Sept 2006

Guikema Jeroen E J, de Boer Conny, Haralambieva Eugenia, Smit Laura A, van Noesel Carel J M, Schuuring Ed, Kluin Philip M

Abstract excerpt

Most chromosomal t(8;14) translocations in sporadic Burkitt lymphomas (BL) are mediated by immunoglobulin class switch recombination (CSR), yet all tumors express IgM, suggesting an incomplete or exclusively monoallelic CSR event. We studied the exact configuration of both the nontranslocated IGH allele and the MYC/IGH breakpoint by applying a combination of low- and high-resolution methods (interphase FISH, DNA...

Topics

Adolescent
Alleles
Burkitt Lymphoma
Cell Line, Tumor
Child
Child, Preschool
Chromosome Breakage
Female
Humans
Immunoglobulin Class Switching
Immunoglobulin Heavy Chains
Male

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Open in PubMed

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PMID: 16736499
DOI: 10.1002/gcc.20345

Genes

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