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Article

Light-chain only multiple myeloma is due to the absence of functional (productive) rearrangement of the IgH gene at the DNA level.

Blood - 15 May 2004

Magrangeas Florence, Cormier Marie-Laure, Descamps Géraldine, Gouy Nadège, Lodé Laurence, Mellerin Marie-Paule, Harousseau Jean-Luc, Bataille Régis, Minvielle Stéphane, Avet-Loiseau Hervé

Abstract excerpt

Although most multiple myeloma (MM) cases are characterized by the detection of a monoclonal immunoglobulin in the serum, about 15% of the patients present only immunoglobulin light chains, detected either in the urine or serum or both. These patients are designated as having light-chain (LC) MM. Using fiber-fluorescent in situ hybridization, and in contrast to patients and myeloma cell lines secreting heavy...

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Share to Chromosomes, Human, Pair 14
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

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Share to Immunoglobulin Switch Region

Share to In Situ Hybridization, Fluorescence

Share to Multiple Myeloma

Share to Translocation, Genetic

Source

Identifiers

PMID: 14715636
DOI: 10.1182/blood-2003-07-2501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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