Article
Light-chain only multiple myeloma is due to the absence of functional (productive) rearrangement of the IgH gene at the DNA level.
Blood - 15 May 2004
Magrangeas Florence, Cormier Marie-Laure, Descamps Géraldine, Gouy Nadège, Lodé Laurence, Mellerin Marie-Paule, Harousseau Jean-Luc, Bataille Régis, Minvielle Stéphane, Avet-Loiseau Hervé
Abstract excerpt
Although most multiple myeloma (MM) cases are characterized by the detection of a monoclonal immunoglobulin in the serum, about 15% of the patients present only immunoglobulin light chains, detected either in the urine or serum or both. These patients are designated as having light-chain (LC) MM. Using fiber-fluorescent in situ hybridization, and in contrast to patients and myeloma cell lines secreting heavy...
Topics
- Alleles
- Chromosomes, Human, Pair 14
- Gene Rearrangement
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Switch Region
- In Situ Hybridization, Fluorescence
- Multiple Myeloma
- Recombination, Genetic
- Translocation, Genetic