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Article

Role of the translocation partner in protection against AID-dependent chromosomal translocations

6 Dec 2009

Abstract excerpt

Chromosome translocations between Ig (Ig) and non-Ig genes are frequently associated with B-cell lymphomas in humans and mice. The best characterized of these is c-myc/IgH translocation, which is associated with Burkitt's lymphoma. These translocations are caused by activation-induced cytidine deaminase (AID), which produces double-strand DNA breaks in both genes. c-myc/IgH translocations are rare events, in part...

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PMID: 19966290
DOI: 10.1073/pnas.0908946107

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Role of the translocation partner in protection against AID-dependent chromosomal translocationsPMID 19966290Read ↗

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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read ↗

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Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine DeaminaseSemantic proximity Read ↗

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Mechanisms of chromosomal translocations in B cell lymphomas.Semantic proximity Read ↗

IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomasSemantic proximity Read ↗

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