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Article

Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination.

Genes, chromosomes & cancer - 1 Feb 2005

Guikema Jeroen E J, Fenton James A L, de Boer Conny, Kleiverda Karin, Brink Antoinette A T P, Raap Anton K, Estrov Zeev, Schuuring Ed, Kluin Philip M

Abstract excerpt

Chromosomal translocations involving the immunoglobulin (Ig) receptor loci usually disrupt and silence these loci. On the basis of observations in follicular lymphoma (FL) with downstream Ig heavy chain (IGH) class switch recombination (CSR), we hypothesized that downstream CSR-mediated chromosomal translocations would leave the V(D)J-Cmu transcription unit intact, thereby still allowing IgM expression from the...

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Source

Identifiers

PMID: 15543623
DOI: 10.1002/gcc.20132

Genes

IGH
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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