Article
Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination.
Genes, chromosomes & cancer - 1 Feb 2005
Guikema Jeroen E J, Fenton James A L, de Boer Conny, Kleiverda Karin, Brink Antoinette A T P, Raap Anton K, Estrov Zeev, Schuuring Ed, Kluin Philip M
Abstract excerpt
Chromosomal translocations involving the immunoglobulin (Ig) receptor loci usually disrupt and silence these loci. On the basis of observations in follicular lymphoma (FL) with downstream Ig heavy chain (IGH) class switch recombination (CSR), we hypothesized that downstream CSR-mediated chromosomal translocations would leave the V(D)J-Cmu transcription unit intact, thereby still allowing IgM expression from the...
Topics
- 3' Flanking Region
- Alleles
- Base Sequence
- Cell Line
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 8
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Class Switching
- Immunoglobulin Heavy Chains
- Immunoglobulin M