Article
VH gene analysis in sporadic Burkitt's lymphoma: somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center.
Leukemia & lymphoma - 1 Jan 2002
Isobe Kouichi, Tamaru Jun-Ichi, Nakamura Shigeo, Harigaya Kenichi, Mikata Atsuo, Ito Hisao
Abstract excerpt
We analyzed the immunoglobulin heavy chain variable region (V(H)) gene in seven cases of sporadic Burkitt's lymphoma (sBL) to elucidate their cell of origin. In particular, we focused on the V(H) gene status of tumor cells involving adjacent germinal center (GC) by microdissecting histological sections. Among the seven V(H) genes V(H)1 family was found in two, V(H)3 in four, and V(H)4 in one. All rearranged V(H)...
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