Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events.

doi:10.1182/blood-2003-05-1632

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events.

Blood - 1 Apr 2004

Babbage Gavin, Garand Richard, Robillard Nelly, Zojer Niklas, Stevenson Freda K, Sahota Surinder S

Abstract excerpt

Isotype switch commonly follows onset of somatic hypermutation in the germinal center (GC), with activation-induced cytidine deaminase (AID) as a prerequisite. Mantle cell lymphoma (MCL) with t(11;14) includes a subset with unmutated (UM) and a minor subset with mutated (MUT) VH genes. Here, we investigated whether switch events and AID expression occur in MCL. In 4 of 6 UM and 4 of 7 MUT MCLs, alternative...

Topics

Alternative Splicing
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Cytidine Deaminase
DNA Primers
Genes, Immunoglobulin
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Class Switching

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Lymphoma, Mantle-Cell

Molecular Sequence Data

Mutation

Reverse Transcriptase Polymerase Chain Reaction

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 14551145
DOI: 10.1182/blood-2003-05-1632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events.PMID 14551145Read ↗

The off-target effects of AID in carcinogenesisSemantic proximity Read ↗

Epigenetics of the antibody and autoantibody responseSemantic proximity Read ↗

Isotype switch variants reveal clonally related subpopulations in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Immunoglobulin class-switch recombination occurs in mantle cell lymphomas.Semantic proximity Read ↗

Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways.Semantic proximity Read ↗

Oncogenic events triggered by AID, the adverse effect of antibody diversificationSemantic proximity Read ↗

The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLsSemantic proximity Read ↗

Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.Semantic proximity Read ↗

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody DiversificationSemantic proximity Read ↗

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseasesSemantic proximity Read ↗

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease ProgressionSemantic proximity Read ↗

Nuclear and cytoplasmic AID in extrafollicular and germinal center B cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.