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Epstein−Barr virus reactivation induces MYC‐IGH spatial proximity and t(8;14) in B cells

1 Mar 2023

Abstract excerpt

Burkitt lymphoma (BL) is a B cell malignancy associated with the Epstein-Barr virus (EBV). Most BL cases are characterized by a t(8;14) chromosomal translocation involving the MYC oncogene and the immunoglobulin heavy chain gene (IGH). The role of EBV in promoting this translocation remains largely unknown. Here we provide the experimental evidence that EBV reactivation from latency leads to an increase in the...

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PMID: 36866703
DOI: 10.1002/jmv.28633

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