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Article

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.

The international journal of neuropsychopharmacology - 1 Jun 2007

Gothelf Doron, Michaelovsky Elena, Frisch Amos, Zohar Ada H, Presburger Gadi, Burg Merav, Aviram-Goldring Ayala, Frydman Moshe, Yeshaya Josepha, Shohat Mordechai, Korostishevsky Michael, Apter Alan, Weizman Abraham

Abstract excerpt

Velocardiofacial syndrome (VCFS) is caused by a microdeletion in chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. The catechol-O-methyltransferase (COMT), residing in the 22q11.2 microdeletion region, is a major candidate gene for genetic susceptibility to neuropsychiatric disorders in VCFS. Individuals with VCFS carrying the low-activity allele (COMTL) are...

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Source

Identifiers

PMID: 16734939
DOI: 10.1017/S1461145706006699

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.PMID 16734939Read ↗

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndromeSemantic proximity Read ↗

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.Semantic proximity Read ↗

Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.Semantic proximity Read ↗

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.Semantic proximity Read ↗

High rates of schizophrenia in adults with velo-cardio-facial syndrome.Semantic proximity Read ↗

Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.Semantic proximity Read ↗

Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility.Semantic proximity Read ↗

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.Semantic proximity Read ↗

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.Semantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia.Semantic proximity Read ↗

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.Semantic proximity Read ↗

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