Article
Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility.
Biological psychiatry - 15 Mar 1998
Karayiorgou M, Gogos J A, Galke B L, Wolyniec P S, Nestadt G, Antonarakis S E, Kazazian H H, Housman D E, Pulver A E
Abstract excerpt
BACKGROUND: Deletions of 1.5-2 MB of chromosome 22q11 have been previously associated with schizophrenia. The deleted region includes proximally the region harboring genes involved in DiGeorge and velocardiofacial syndromes. Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore...
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