Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.

The international journal of neuropsychopharmacology - 1 May 2008

Michaelovsky Elena, Gothelf Doron, Korostishevsky Michael, Frisch Amos, Burg Merav, Carmel Miri, Steinberg Tamar, Inbar Dov, Apter Alan, Weizman Abraham

Abstract excerpt

The 22q11.2 deletion syndrome (22q11.2DS) is the most common hemizygous deletion syndrome in humans. In addition to a wide range of physical abnormalities 22q11.2DS subjects show high prevalence of several psychiatric disorders. In our previous study we showed that the low-activity allele (158Met) of the COMT gene is a risk factor for attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention Deficit Disorder with Hyperactivity
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Chromosomes, Human, Pair 22

Share to Methionine

Share to Obsessive-Compulsive Disorder

Share to Polymorphism, Single-Stranded Conformational

Share to Valine

Source

Identifiers

PMID: 17949513
DOI: 10.1017/S1461145707008085

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.PMID 17949513Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

IQ and hemizygosity for the Val158 Met functional polymorphism of COMT in 22q11DS.Semantic proximity Read ↗

Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects.Semantic proximity Read ↗

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.Semantic proximity Read ↗

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.Semantic proximity Read ↗

Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.Semantic proximity Read ↗

The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.Semantic proximity Read ↗

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11.Semantic proximity Read ↗

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.Semantic proximity Read ↗

A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.