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Article

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.

Psychiatric genetics - 1 Dec 2014

Radoeva Petya D, Coman Ioana L, Salazar Cynthia A, Gentile Karen L, Higgins Anne Marie, Middleton Frank A, Antshel Kevin M, Fremont Wanda, Shprintzen Robert J, Morrow Bernice E, Kates Wendy R

Abstract excerpt

Velocardiofacial (VCFS; 22q11.2 deletion) syndrome is a genetic disorder that results from a hemizygous deletion of the q11.2 region on chromosome 22, and is associated with greatly increased risk for psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia. There is emerging evidence for the involvement of catechol-O-methyltransferase (COMT) and proline dehydrogenase (oxidase) 1 (PRODH)...

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Share to Adolescent
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child Development Disorders, Pervasive

Share to Chromosomes, Human, Pair 22

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Share to Proline Oxidase

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Source

Open in PubMed Open full text

Identifiers

PMID: 25325218
DOI: 10.1097/YPG.0000000000000062
PMCID: PMC4284058

Genes

COMT
PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.PMID 25325218Read ↗

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.Semantic proximity Read ↗

PRODH rs450046 and proline x COMT Val¹⁵⁸ Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders.Semantic proximity Read ↗

Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.Semantic proximity Read ↗

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndromeSemantic proximity Read ↗

Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.Semantic proximity Read ↗

The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD.Semantic proximity Read ↗

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects.Semantic proximity Read ↗

Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.Semantic proximity Read ↗

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