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Article

Prefrontal broadband noise, working memory, and genetic risk for schizophrenia.

The American journal of psychiatry - 1 Mar 2004

Winterer Georg, Coppola Richard, Goldberg Terry E, Egan Michael F, Jones Douglas W, Sanchez Carmen E, Weinberger Daniel R

Abstract excerpt

OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal...

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Source

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PMID: 14992975
DOI: 10.1176/appi.ajp.161.3.490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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