Prefrontal broadband noise, working memory, and genetic risk for schizophrenia.

doi:10.1176/appi.ajp.161.3.490

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Prefrontal broadband noise, working memory, and genetic risk for schizophrenia.

The American journal of psychiatry - 1 Mar 2004

Winterer Georg, Coppola Richard, Goldberg Terry E, Egan Michael F, Jones Douglas W, Sanchez Carmen E, Weinberger Daniel R

Abstract excerpt

OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal...

Topics

Adult
Arousal
Attention
Brain Mapping
Cerebral Cortex
Electroencephalography
Evoked Potentials
Female
Genetic Predisposition to Disease
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory, Short-Term

Middle Aged

Models, Genetic

Neuropsychological Tests

Pitch Discrimination

Prefrontal Cortex

Psychometrics

Source

Open in PubMed

Identifiers

PMID: 14992975
DOI: 10.1176/appi.ajp.161.3.490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prefrontal broadband noise, working memory, and genetic risk for schizophrenia.PMID 14992975Read ↗

Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophrenia.Semantic proximity Read ↗

A shared low-frequency oscillatory rhythm abnormality in resting and sensory gating in schizophrenia.Semantic proximity Read ↗

Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia.Semantic proximity Read ↗

Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.Semantic proximity Read ↗

Genetic and disorder-specific aspects of resting state EEG abnormalities in schizophrenia.Semantic proximity Read ↗

Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.Semantic proximity Read ↗

Differential Vulnerability of Stimulus-Locked and Persistent Gamma Oscillations: Implications in SchizophreniaSemantic proximity Read ↗

Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium.Semantic proximity Read ↗

Reduced mismatch negativity to frequency deviants and altered non-oscillatory gamma-band power in first episode psychosisSemantic proximity Read ↗

Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network.Semantic proximity Read ↗

Neural network dynamics underlying gamma synchronization deficits in schizophreniaSemantic proximity Read ↗

Aperiodic EEG features of cognition: A systematic reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.