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Article

Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism, and Neuronal Oscillatory Activity.

Cerebral cortex (New York, N.Y. : 1991) - 5 Jul 2019

Steiner Genevieve Z, Fernandez Francesca M, Coles Madilyn, Karamacoska Diana, Barkus Emma, Broyd Samantha J, Solowij Nadia, Watson Owen T, Chiu Christine L, Lind Joanne M, Barry Robert J

Abstract excerpt

The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. Schizotypy is associated with an increased risk of psychosis, with some studies implicating similar neurobiological mechanisms to schizophrenia. The present study sought to interrogate the link between the COMT Val158Met polymorphism and...

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Source

Identifiers

PMID: 30084963
DOI: 10.1093/cercor/bhy171

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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